![]() By understanding the mechanisms behind drug interactions and staying alert for toxicities, we can help make drug therapy safer and reduce the fear of drug interactions. Then they should be reported to regulatory bodies and submitted to journals. Observations of drug interactions should be confirmed, if possible, by serum drug concentrations. Physicians need better tools, but, in the meantime, understanding the nuances of the cytochrome P450s will help take the fear out of prescribing.īecause the best evidence for clinically relevant drug interactions comes from case reports, prescribing physicians can have a major impact. We also need more sensitive post-marketing surveillance tools to identify important drug interactions that become evident over time in diseased hosts and that were not seen in pre-marketing studies of healthy volunteers. More research during the early stages of drug development is required to identify new interactions, define mechanisms of older interactions, and examine the safety of new drugs from classes that are known to cause interactions. This handbook is concise, up-to-date and, unlike most desk references, it is not limited by class-related statements that may falsely and unnecessarily restrict therapeutic options. One of the best pocket reference guides is The Top 100 Drug Interactions by Hansten and Horn ( 3. Although no one can be expected to know all drug interactions, good resources are available. Bolognia MD, in Dermatology, 2018 Conclusionĭealing with drug interactions is a challenge in clinical practice. Keep all medicines in their original containers so they can be easily identified.Jean L. Obtain all your medicines from one pharmacy and tell your pharmacist about any OTC, supplements, herbs, or vitamins that you take. Alcohol can change medicine absorption and may increase or decrease the effectiveness of many medicines.īe sure to tell your healthcare provider and pharmacist about all medicines you are taking, both prescription and nonprescription. Never take medicine with alcoholic drinks. This may change the way the medicine works.Ĭheck with your pharmacist or healthcare provider before taking vitamin pills at the same time you take medicine-vitamins and minerals can interact with some medicines.ĭo not mix medicine into hot drinks, because the heat from the drink may destroy the effectiveness of the medicine. Take medicine with a full glass of water unless told otherwise by your pharmacist or healthcare provider.ĭo not stir medicine into your food or take capsules apart (unless directed by your pharmacist or healthcare provider). Even over-the-counter medicines can interact with foods, beverages, or supplements. Read directions, warnings, and interaction precautions printed on all medicine labels and instructions. If you do not understand something, or think you need more information, ask your healthcare provider or pharmacist. Read the prescription label on the container. What you should remember about food-medicine interactionsĪsk your pharmacist or healthcare provider if there are foods, beverages, vitamins, or supplements you should avoid with your medicines. Be sure to ask your healthcare provider or pharmacist for specific directions on eating before or after taking any medicine. Other medicines are recommended to be taken with food. ![]() Sometimes, taking medicines at the same time you eat may interfere with the way your stomach and intestines absorb medicine. ![]() Not all medicines are affected by food, but many can be affected by what you eat and when you eat it. ![]() Some medicines are only absorbed if they are taken with a full meal or even a meal high in fat content. Grapefruit juice can interfere with some blood pressure medicines and organ transplant medicines by increasing their metabolic breakdown. These include beer, red wine, chocolate, processed meat, avocados, and some cheeses. One kind of antidepressants called MAO inhibitors are dangerous when mixed with foods or drinks that contain tyramine. Dairy products may blunt the infection-fighting effects of tetracycline. Some green leafy vegetables can cancel out the effects of warfarin, an anticoagulant medicine. For example, the acidity of fruit juice may decrease the effectiveness of antibiotics such as penicillin. This reduces their absorption or speeds their elimination. Some nutrients can affect the way you metabolize certain medicines by binding with the medicine's ingredients. These include antacids, vitamins, iron pills, herbs, supplements, and beverages. What happens during a food-medicine interaction?įood-medicine interactions can happen with both prescription and over-the-counter (OTC) medicines.
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